کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1862917 | 1037618 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Significant residue features revealed by eigenvalue decomposition analysis of BLOSUM matrices
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک و نجوم (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Significant residue features revealed by eigenvalue decomposition analysis of BLOSUM matrices Significant residue features revealed by eigenvalue decomposition analysis of BLOSUM matrices](/preview/png/1862917.png)
چکیده انگلیسی
Here we attempt to characterize protein evolution by residue features which dominate residue substitution in homologous proteins. Evolutionary information contained in residue substitution matrix is abstracted with the method of eigenvalue decomposition. Top eigenvectors in the eigenvalue spectrums are analyzed as function of the level of similarity, i.e. sequence identity (SI) between homologous proteins. It is found that hydrophobicity and volume are two significant residue features conserved in protein evolution. There is a transition point at SIâ45%. Residue hydrophobicity is a feature governing residue substitution as SI⩾45%. Whereas below this SI level, residue volume is a dominant feature.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physics Letters A - Volume 372, Issue 13, 24 March 2008, Pages 2282-2285
Journal: Physics Letters A - Volume 372, Issue 13, 24 March 2008, Pages 2282-2285
نویسندگان
Li-Mei Zhang, Xin Liu,