An Evanescent Wave Fiber Optic Biosensor Based on Metal-Enhanced Fluorescence (MEF)

Fiber-optic biosensors play a significant role in the development of biosensors because they can provide miniaturized and lowcost systems. Recently, there have been explosive developments in the Metal-Enhanced Fluorescence (MEF) technology to favorably modify the spectral properties and to alleviate photo-physical constraints. We report the development of core/shell nanoparticles with the silver core and silica shell for potential applications in fiber optic biosensor. The fluorescence intensity of the fluorescence probe doped core/shell nanoparticles is approximately 40-fold higher than that without core/shell nanoparticles doping. In addition, the enhanced emission of fluorescence intensity in different solvents changes from 1.2-to 100-fold as compared to the control sample.