A Graphene Oxide–Rhodamine 6G Nanocomposite as Turn-on Fluorescence Probe for Selective Detection of DNA

An electrostatic nanocomposite from Rhodamine 6G (R6G) and GO for the cost-effective, label-free, facile, sensitive and selective detection of DNA was constructed. Upon the interaction between positively charged dye and negatively charged GO, the charge-transfer complex R6G+GO- formed and significantly fluorescence quenching was observed. Due to the high electrostatic and non-covalent interactions between R6G and DNA, in the present of DNA, the interaction between R6G and GO was disturbed, which will turn on the fluorescence of R6G. The key advance of this R6G+GO- biosensor platform is attributed to the high quenching and absorbing capabilities of GO, which make it an effective candidate for DNA detection.