کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1902143 1534304 2016 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
From DNA damage to functional changes of the trabecular meshwork in aging and glaucoma
ترجمه فارسی عنوان
از آسیب DNA تا تغییرات عملکردی در شبکه ترابکولار در پیری و بیماری آب سیاه
کلمات کلیدی
اتاقک قدامی؛ مایع زلالیه؛ شبکه اکتین اتصال عرضی؛ ماهیچه مژکی؛ شبکه ترابکولار اسکلرا ؛ مواد خارج سلولی/ماتریس؛ لایه گلیکوکالیکس اندوتلیال؛ اندوتلین؛ گلوتاتیون؛
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Oxidative stress as pathogenetic mechanism for glaucoma is proposed.
• Trabecular meshwork impairment among senescence genetics and cellularity.
• The glaucomatous cascade include mitochondrial and endothelial dysfunction.
• Glaucomatous proteoma as biomarkers signals between anterior and posterior segment.

Glaucoma is a degenerative disease of the eye. Both the anterior and posterior segments of the eye are affected, extensive damage being detectable in the trabecular meshwork and the inner retina-central visual pathway complex. Oxidative stress is claimed to be mainly responsible for molecular damage in the anterior chamber. Indeed, oxidation harms the trabecular meshwork, leading eventually to endothelial cell decay, tissue malfunction, subclinical inflammation, changes in the extracellular matrix and cytoskeleton, altered motility, reduced outflow facility and (ultimately) increased IOP. Moreover, free radicals are involved in aging and can be produced in the brain (as well as in the eye) as a result of ischemia, leading to oxidation of the surrounding neurons. Glaucoma-related cell death occurs by means of apoptosis, and apoptosis is triggered by oxidative stress via (a) mitochondrial damage, (b) inflammation, (c) endothelial dysregulation and dysfunction, and (d) hypoxia. The proteomics of the aqueous humor is significantly altered in glaucoma as a result of oxidation-induced trabecular damage. Those proteins whose aqueous humor levels are increased in glaucoma are biomarkers of trabecular meshwork impairment. Their diffusion from the anterior to the posterior segment of the eye may be relevant in the cascade of events triggering apoptosis in the inner retinal layers, including the ganglion cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 29, August 2016, Pages 26–41
نویسندگان
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