کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1904171 1534486 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does Down's syndrome support the homocysteine theory of atherogenesis?: Experience in elderly subjects with trisomy 21
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Does Down's syndrome support the homocysteine theory of atherogenesis?: Experience in elderly subjects with trisomy 21
چکیده انگلیسی

Down syndrome (DS) is generally considered as an “atheroma-free model”. In this preliminary study, we investigated homocysteine, folate and Vitamin B12 levels in 13 DS patients (male, average age 60 years) and 20 age-matched individuals. We also studied lipid fractions, and polymorphisms for Cystothionine β-synthase (CBS), 5,10-methyl-tetrahydro-folate reductase (MTHFR) and apolipoprotein E (Apo-E) genes. However, DS patients with the MTHFR TT genotype showed an increased of plasma homocysteine (tHcy). Our results indicate that this group of “healthy old” Down syndrome patients, although showing some classical biochemical risk factors for atherosclerosis, did not suffer clinical cardiovascular alterations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Gerontology and Geriatrics - Volume 43, Issue 3, November–December 2006, Pages 381–387
نویسندگان
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