کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1904310 | 1534491 | 2006 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Different MRI findings for normal elderly and very mild Alzheimer's disease in a community: Implications for clinical practice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Different MRI findings for normal elderly and very mild Alzheimer's disease in a community: Implications for clinical practice Different MRI findings for normal elderly and very mild Alzheimer's disease in a community: Implications for clinical practice](/preview/png/1904310.png)
چکیده انگلیسی
To investigate magnetic resonance imaging (MRI) findings of very mild dementia, 485 participants were randomly selected in a community. Three hundred and forty participants were of Clinical Dementia Rating (CDR) 0 (healthy), 113 were of CDR 0.5 (questionable dementia), and 32 were of CDR 1 and 2 (including 20 Alzheimer's disease, AD). Cortical atrophy, white matter lesion, etc., were visually assessed. We found that each part of the brain showed atrophy in older adults for CDR 0. For CDR 0.5, the relationships between MRI findings and age were weaker, and for AD, there were no such relationship. Atrophy related with dementia severity was found to be limited to the lateral and medial temporal lobes. For CDR 0.5, amygdala atrophy was the only finding indicating CDR effect but no age effect. The amygdala or anterior entorhinal atrophy is important for discriminating very mild dementia from normal elderly.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Gerontology and Geriatrics - Volume 42, Issue 1, JanuaryâFebruary 2006, Pages 59-71
Journal: Archives of Gerontology and Geriatrics - Volume 42, Issue 1, JanuaryâFebruary 2006, Pages 59-71
نویسندگان
Hiroshi Ishii, Kenichi Meguro, Satoshi Yamaguchi, Kazumi Hirayama, Michio Tabuchi, Etsuro Mori, Atsushi Yamadori,