کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1914089 1535149 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical features and recovery patterns of acquired non-thyrotoxic hypokalemic paralysis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Clinical features and recovery patterns of acquired non-thyrotoxic hypokalemic paralysis
چکیده انگلیسی

ObjectiveTo report the clinical features and recovery patterns of patients with non-thyrotoxic acquired hypokalemic paralysis.MethodsThe clinical and laboratory records of 11 consecutive patients with acquired non-thyrotoxic hypokalemic paralysis were reviewed and compared with those of 3 patients with thyrotoxic periodic paralysis (TPP). The causes of potassium wasting were diarrhea (n = 4), alcohol abuse (n = 2), pseudoaldosteronism (n = 2), primary aldosteronism (n = 1), distal renal tubular acidosis associated with Sjögren's syndrome (n = 1) and an unknown cause (n = 1).ResultsThree of the 11 patients had prominently asymmetric limb weakness, and 2 had predominant upper limb weakness. On admission, mean serum potassium and creatine kinase (CK) levels of patients with acquired hypokalemic paralysis on admission were 1.8 mEq/L and 4,075 U/mL, respectively, and the mean duration between admission and independent walking was 6.8 days (range, 2–31 days). Despite clinical recovery, 10 patients still presented with increased CK levels after several days (mean of maximum levels, 10,519 U/mL). In addition, normalization of serum potassium levels in patients with acquired hypokalemic paralysis patients was much slower compared to that in patients with TPP. One patient with acquired hypokalemic paralysis developed ventricular fibrillation, whereas all 3 patients with TPP had symmetric proximal and lower limb-dominant weakness and exhibited complete recovery from paralysis as well as normalized serum potassium levels within 24 h.ConclusionsIn patients with acquired non-thyrotoxic hypokalemic paralysis, asymmetric or upper limb-dominant weakness of the extremities is observed. Despite clinical improvement after treatment, normalization of serum potassium and CK levels is often delayed, and therefore, careful monitoring for cardiac and renal complications is required.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 313, Issues 1–2, 15 February 2012, Pages 42–45
نویسندگان
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