کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1914271 1535160 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional parkin promoter polymorphism in Parkinson's disease: New data and meta-analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Functional parkin promoter polymorphism in Parkinson's disease: New data and meta-analysis
چکیده انگلیسی

BackgroundA functional SNP (rs9347683) in the promoter region of the parkin gene had been implicated as a risk factor in older Parkinson's disease (PD) patients.MethodsUsing a case–control methodology, we genotyped the SNP in the promoter region of the parkin gene to investigate their association with risk of PD and conducted a pooled analysis of published papers in the English literature.ResultsA total of 1087 study subjects comprising 595 patients with PD and 492 unrelated healthy controls were recruited. The frequency of “GG” genotype in the elderly sub-group (≥ 65 years) was higher in PD compared to controls (OR = 1.11) though we did not observe any difference in allele or genotype frequencies between the cases and the controls (P > 0.05) in the overall PD population. Those with genotype “GG” were associated with a higher Hoehn–Yahr stage compared with PD patients carrying “GT” + “TT” (P = 0.040). A pooled analysis involving more than > 3000 subjects revealed that the frequency of genotypes in PD patients did not differ from the controls (OR = 0.98, 95% CI: 0.86–1.12). However, in the group ≥ 65 years of age, the “GG” genotype was higher in PD (OR = 1.51, 95% CI: 1.06–2.13, P = 0.020) among the ethnic Chinese.ConclusionsWhile we did not demonstrate a significant association of the parkin promoter polymorphism with PD in our sample, the pooled data suggest that the variant may increase the risk of PD in the more elderly population among the ethnic Chinese, suggesting possible ethnicity-specific effect. Further in vitro and in vivo studies to evaluate this functional parkin variant are warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 302, Issues 1–2, 15 March 2011, Pages 68–71
نویسندگان
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