کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1914439 | 1645458 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Relationship between orthostatic hypotension and cognitive impairment in the elderly Relationship between orthostatic hypotension and cognitive impairment in the elderly](/preview/png/1914439.png)
Background and purposeTo determine the relationship between orthostatic hypotension (OH) and cognitive function in elderly subjects with memory complaints.MethodsWe studied the association between cognitive function and OH in 495 consecutive elderly outpatients attending a memory centre. Blood pressure (BP) was measured in a sitting and standing position. We examined cognitive function using a validated comprehensive battery of neuropsychological tests, the cognitive efficiency profile (CEP) assessing the main cognitive areas. Subjects were classified into 4 categories according to their cognitive status: normal cognitive function, mild cognitive impairment (MCI), Alzheimer's disease (AD) or vascular dementia (VaD).ResultsIn this population, 76 ± 8 years of age (women 72%), 18% had normal cognitive function, 28% had MCI, 47% AD, and 7% VaD. Hypertension was observed in 74% of patients. OH was present in 14% of subjects (n = 69). After adjustment for age, education level, systolic BP, diastolic BP, weight, and antihypertensive drugs, subjects with OH had worse cognitive function than those without OH (CEP score 50 ± 24 vs 56 ± 22, p < 0.05). Moreover, a significant relationship was observed between OH and cognitive status (normal cognitive function, MCI, AD, or VaD). OH was present in 22% in VaD subjects, 15% in AD subjects, 12% in MCI subjects and 4% in normal control subjects (p < 0.01 for overall test).ConclusionOur results showed an association between OH and cognitive impairment and emphasize the need for longitudinal studies designed to evaluate the nature of the relationship between OH and cognitive decline.
Journal: Journal of the Neurological Sciences - Volume 299, Issues 1–2, 15 December 2010, Pages 45–48