کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1914737 1535171 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A giant MS plaque mimicking PML during natalizumab treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
A giant MS plaque mimicking PML during natalizumab treatment
چکیده انگلیسی

We describe a patient with a giant MS plaque developing during natalizumab administration whose clinical presentations mimicked PML. This 27 year-old man developed new onset confusion, altered behavior, left hemianesthesia and worsening dysarthria, gait and balance with a new, large, rim-enhancing, temporoparietal subcortical lesion after four infusions of natalizumab. Cerebrospinal JC virus polymerase chain reaction was negative. No neutralizing antibody to natalizumab was detected. Following discontinuation of natalizumab, plasma exchange, and a single dose of 1000 mg of methylprednisolone, he demonstrated clinical and radiographic improvement. Distinguishing PML from MS may be very difficult in some instances. The frequency with which an aggressive demyelinating disorder due to MS occurs during treatment with natalizumab remains to be determined.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 291, Issues 1–2, 15 April 2010, Pages 110–113
نویسندگان
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