کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1914815 1535175 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain structural changes in essential tremor: Voxel-based morphometry at 3-Tesla
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Brain structural changes in essential tremor: Voxel-based morphometry at 3-Tesla
چکیده انگلیسی

BackgroundAbnormalities in cerebello-thalamo-cortical pathways have been suggested as a basis for essential tremor (ET). Two voxel-based morphometry (VBM) studies, each using a 1.5-T magnet, evaluated ET patients, leading to contradictory results. Using a 3-T magnet, we assessed whether white or gray matter changes occurred in ET patients vs. controls.MethodsWe recruited 19 ET patients (mean age 69.8 ± 9.4 years) and 20 age and gender-matched controls. 3-T MRI data were analyzed using the Statistical Parametric Mapping (SPM) 5 package.ResultsIn case–control comparisons, white matter changes were seen in several areas (right cerebellum, left medulla, right parietal lobe, and right limbic lobe); gray matter changes were seen in several areas as well (bilateral cerebellum, bilateral parietal lobes, right frontal lobe, and right insula) (p < 0.001, uncorrected at a voxel level). Compared with controls, ET patients with severe tremor had white matter changes in the midbrain, both occipital lobes, and right frontal lobe, and gray matter changes bilaterally in the cerebellum (p < 0.001, uncorrected at a voxel level).ConclusionsStructural white and gray abnormalities may be detected in ET patients using VBM and a high-field MRI scanner. Such changes may be related to the pathological substrates associated with this disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 287, Issues 1–2, 15 December 2009, Pages 138–142
نویسندگان
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