کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1915024 | 1535177 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS) Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)](/preview/png/1915024.png)
Amyotrophic lateral sclerosis (ALS) mainly affects the motor neurons but may also include other organs such as the skin. We aimed to determine whether matrix metalloproteinases could provide a link between neuronal degeneration and skin alterations in ALS.We measured CSF, serum and skin tissue MMP-2 and MMP-9 using ELISA and malondialdehyde (MDA), a marker of lipid peroxidation, using High Performance Liquid Chromatography (HPLC) in 54 ALS patients and 36 controls.We found CSF and skin MMP-9 to be elevated in ALS as compared to controls (p < 0.001, p = 0.03, respectively). We observed CSF MMP-9 to be highest in patients with a rapid progressive course of disease (p = 0.008). In contrast, we found no significant differences of CSF, serum or skin concentrations of MMP-2 as compared to controls. CSF MMP-2 concentrations decreased with duration of disease (p = 0.04, R = − 0.31). MDA was elevated in serum of ALS (p < 0.001), though no correlation with MMP-2 or MMP-9 was observed.Our findings indicate a general upregulation of MMP-9 in ALS. MMP-9 seems to play a role in both neurodegeneration and skin changes in ALS and could thus be a common factor linking otherwise distant aspects of disease pathology.
Journal: Journal of the Neurological Sciences - Volume 285, Issues 1–2, 15 October 2009, Pages 62–66