کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1915024 1535177 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)
چکیده انگلیسی

Amyotrophic lateral sclerosis (ALS) mainly affects the motor neurons but may also include other organs such as the skin. We aimed to determine whether matrix metalloproteinases could provide a link between neuronal degeneration and skin alterations in ALS.We measured CSF, serum and skin tissue MMP-2 and MMP-9 using ELISA and malondialdehyde (MDA), a marker of lipid peroxidation, using High Performance Liquid Chromatography (HPLC) in 54 ALS patients and 36 controls.We found CSF and skin MMP-9 to be elevated in ALS as compared to controls (p < 0.001, p = 0.03, respectively). We observed CSF MMP-9 to be highest in patients with a rapid progressive course of disease (p = 0.008). In contrast, we found no significant differences of CSF, serum or skin concentrations of MMP-2 as compared to controls. CSF MMP-2 concentrations decreased with duration of disease (p = 0.04, R = − 0.31). MDA was elevated in serum of ALS (p < 0.001), though no correlation with MMP-2 or MMP-9 was observed.Our findings indicate a general upregulation of MMP-9 in ALS. MMP-9 seems to play a role in both neurodegeneration and skin changes in ALS and could thus be a common factor linking otherwise distant aspects of disease pathology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 285, Issues 1–2, 15 October 2009, Pages 62–66
نویسندگان
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