کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1915115 | 1535176 | 2009 | 4 صفحه PDF | دانلود رایگان |
The majority of autoimmune disorders are characterized by female predominance. Several mechanisms have been proposed as explanations for this gender bias, among them X chromosome inactivation. An increased frequency of skewed X inactivation has been found in some autoimmune disorders, like scleroderma and autoimmune thyroid disease, and may thus offer a possible explanation for the female predominance.Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, with pathological features of an autoimmune disorder. The incidence of MS in females is approximately twofold compared to the incidence in males. X inactivation does not seem to be part of the explanation for the gender bias in MS.This paper reviews the possible role of X chromosome inactivation in some autoimmune diseases, and describes a recent study of X inactivation in females with MS.
Journal: Journal of the Neurological Sciences - Volume 286, Issues 1–2, 15 November 2009, Pages 43–46