کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1915115 1535176 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gender bias in autoimmune diseases: X chromosome inactivation in women with multiple sclerosis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Gender bias in autoimmune diseases: X chromosome inactivation in women with multiple sclerosis
چکیده انگلیسی

The majority of autoimmune disorders are characterized by female predominance. Several mechanisms have been proposed as explanations for this gender bias, among them X chromosome inactivation. An increased frequency of skewed X inactivation has been found in some autoimmune disorders, like scleroderma and autoimmune thyroid disease, and may thus offer a possible explanation for the female predominance.Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, with pathological features of an autoimmune disorder. The incidence of MS in females is approximately twofold compared to the incidence in males. X inactivation does not seem to be part of the explanation for the gender bias in MS.This paper reviews the possible role of X chromosome inactivation in some autoimmune diseases, and describes a recent study of X inactivation in females with MS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 286, Issues 1–2, 15 November 2009, Pages 43–46
نویسندگان
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