کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1915419 | 1535186 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cardiac parasympathetic dysfunction concurrent with cardiac sympathetic denervation in Parkinson's disease Cardiac parasympathetic dysfunction concurrent with cardiac sympathetic denervation in Parkinson's disease](/preview/png/1915419.png)
We aimed to characterize the relationship between cardiac sympathetic and parasympathetic dysfunction employing cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake and other autonomic function parameters in Parkinson's disease (PD). 79 PD patients were studied. We performed 123I-MIBG myocardial scintigraphy to assess the extent of cardiac sympathetic denervation. Electrocardiogram readings at rest and postural change in blood pressure were also examined. Coefficient variation of RR intervals (CVR-R) was used as an index for cardiac parasympathetic activity. Cardiac 123I-MIBG uptake did not vary significantly among the Hoehn–Yahr (H–Y) stages. There was a significant correlation between cardiac 123I-MIBG uptake and CVR-R (early, r = 0.457, p < 0.001; late, r = 0.442, p < 0.001). While the correlation was present among the patients who had had the disease less than two years (early, r = 0.558, p < 0.001; late, r = 0.530, p < 0.001), the patients with the disease duration longer than two years did not have such a significant correlation. Age, disease duration, corrected QT interval, or postural blood pressure change did not correlate with cardiac 123I-MIBG uptake. Orthostatic hypotension was observed in 13 out of 72 subjects, and reduced CVR-R was a major determinant for the development of orthostatic hypotension. We conclude that cardiac parasympathetic dysfunction occurs concurrent with sympathetic denervation as revealed by 123I-MIBG myocardial scintigraphy in PD and contributes to the development of orthostatic hypotension.
Journal: Journal of the Neurological Sciences - Volume 276, Issues 1–2, 15 January 2009, Pages 79–83