کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1915750 | 1535194 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Measurement of the 11C-flumazenil binding in the visual cortex predicts the prognosis of hemianopia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In order to determine whether functional neuroimaging studies can predict the prognosis of hemianopia due to organic cerebral disorders, we studied 8 patients (6 men and 2 women; age, 56.0 ± 8.6 years) with homonymous hemianopia and compared them with 15 normal subjects (6 men and 9 women; age, 54.3 ± 4.4 years). The cerebral glucose metabolism and 11C-flumazenil (FMZ) binding were measured by positron emission tomography, more than 1 month after the onset of the condition. Bilateral regions of interest (ROIs) were selected in the striate cortex, extrastriate cortex, cuneus and thalamus. Further, semi-quantitative data on the cerebral glucose metabolism and FMZ binding were obtained for the ROIs and compared with the data obtained for homologous regions in the contralateral hemisphere by calculating the ipsilateral/contralateral (I/C) ratio. The I/C ratios for the cerebral glucose metabolism and FMZ binding in the striate cortex were significantly low in the patients (glucose metabolism, P < 0.0005; FMZ binding, P < 0.005), while the ratio for the FMZ binding in the cuneus increased (P < 0.0005). We observed that 5 patients, whose I/C ratio for the FMZ binding in the striate cortex was > 0.850, experienced an improvement in their visual field, while that 3 patients with lower I/C ratios did not. The FMZ-PET may be useful to predict the prognosis of hemianopia in the chronic phase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 268, Issues 1â2, 15 May 2008, Pages 102-107
Journal: Journal of the Neurological Sciences - Volume 268, Issues 1â2, 15 May 2008, Pages 102-107
نویسندگان
Yukihisa Suzuki, Chiharu Horie, Motohiro Kiyosawa, Tadashi Nariai, Manabu Mochizuki, Keiichi Oda, Yuichi Kimura, Kiich Ishiwata, Kenji Ishii,