کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1915835 | 1535195 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Decreased peripheral nerve damage after ischemia-reperfusion injury in mice lacking TNF-alpha
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
We sought to explore the role of tumor necrosis factor-alpha (TNF-α) in the pathogenesis of peripheral nerve ischemia-reperfusion (IR) injury. We established an ischemia-reperfusion model in wild type (WT) and TNF-α knockout (KO) mice. Electrophysiology, behavioral score and morphological indices (edema and ischemic fiber degeneration [IFD]) were examined to determine the influence of TNF-α on peripheral nerve structure and function following ischemia followed by reperfusion. TNF-α and nuclear factor-kappa B (NF-κB) expression were evaluated using immunohistochemistry. TNF-α KO mice, compared to WT had, in sciatic nerve, marked improvement in nerve pathology. This is a region subject to moderate ischemia-reperfusion injury. There was also a significant improvement in electrophysiological and some behavioral indices. TNF-α and NF-κB expression were abundant in sciatic-tibial nerves of WT mice subjected to IR, but there was less, or complete lack of, expression in ischemic nerve of TNF-α KO mice. We conclude that TNF-α plays an essential role in the pathogenesis of peripheral nerve ischemia-reperfusion injury, possibly partly through the activation of NF-κB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 267, Issues 1â2, 15 April 2008, Pages 107-111
Journal: Journal of the Neurological Sciences - Volume 267, Issues 1â2, 15 April 2008, Pages 107-111
نویسندگان
Yanping Wang, Nobutoshi Kawamura, James D. Schmelzer, Ann M. Schmeichel, Phillip A. Low,