کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1915903 1535199 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Efficacy of low-dose, add-on therapy of clobazam (CLB) is produced by its major metabolite, N-desmethyl-CLB
چکیده انگلیسی

We evaluated the efficacy of low-dose, add-on therapy of CLB in adults with refractory epilepsy. 28 patients were included: 12 with temporal lobe epilepsy (TLE), 14 with extratemporal lobe epilepsy (ETLE) and 2 with symptomatic generalized epilepsy (SGE). CLB was added with the initial dose of 2.5 mg/day and increased to the optimal dose (mean, 5.6 mg/day). The mean observation period was 7.9 months. As compared with the baseline period, 14 out of 28 patients (50%) obtained an obviously good seizure control: 6 seizure free and 8 more than 50% of seizure reduction. The 14 patients comprised of 4 TLE, 8 ETLE and 2 SGE. In seizure type analysis, 26% of complex partial seizures (CPS), 64% of simple partial seizures (SPS) and 86% of generalized tonic–clonic seizures (GTC) showed a good control. Blood level of N-desmethyl-CLB in the steady state was higher in seizure-free group of 6 patients, and N-desmethyl-CLB blood level/dose per kg body weight correlated significantly to seizure control (p = 0.0167). Our data show that even in low dose CLB was effective to patients with refractory epilepsy who had higher blood level of N-desmethyl-CLB.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 263, Issues 1–2, 15 December 2007, Pages 44–48
نویسندگان
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