کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1915986 | 1535198 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Nuclear factor-κB activity was analyzed in multiple sclerosis (MS) patients during the course of a methylprednisolone pulse therapy. Molecular effects were evaluated using lymphocytes derived from 20 MS patients before and after therapy and 24 healthy individuals. All patients responded to treatment clinically. The mean level of DNA-binding p65 in MS was proportionate to that of healthy controls, but was significantly decreased directly after therapy whereas the level of DNA-binding p50 was significantly elevated prior to therapy and remained unchanged. In summary, pulse therapy resulted in a decreased level of activated p65 NF-κB subunits leading to decreased levels of transcriptionally active pro-inflammatory NF-κB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 264, Issues 1–2, 15 January 2008, Pages 145–150
Journal: Journal of the Neurological Sciences - Volume 264, Issues 1–2, 15 January 2008, Pages 145–150
نویسندگان
Martin Eggert, Robert Goertsches, Ulrike Seeck, Silvia Dilk, Gunther Neeck, Uwe K. Zettl,