کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1916277 1535205 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation-flow coupling differentiates between vascular and Alzheimer type of dementia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Activation-flow coupling differentiates between vascular and Alzheimer type of dementia
چکیده انگلیسی

The activation-flow coupling describes a mechanism, which adapts local cerebral blood flow in accordance with the underlying neuronal activity. It was suggested that the mechanism helps in differentiation between Alzheimer and vascular type of dementia. We combined EEG and Doppler techniques and assessed integrity of the activation-flow coupling in the occipital cortex utilizing a visual stimulation task. Alzheimer patients (MMSE: 18 ± 8 points, DemTect 5 ± 4 points) without signs of vascular lesions on a MRI scan and vascular demented patients (MMSE: 20 ± 6 points, DemTect 6 ± 3 points; MRI Fazekas score 7 ± 3 points) were compared with data from an age-matched control group. Evoked flow velocity responses in the posterior cerebral artery were analysed according to a control system model specifying the parameters gain, attenuation, natural frequency and rate time. Evoked potentials were analysed for the N75–P100 amplitude difference. Vascular demented patients exhibited a significant decreased gain parameter and increased attenuation parameter indicating severe cerebrovascular dysfunction. Also, the potential amplitudes were significantly decreased indicating neuronal damage due to the vascular disease process. Alzheimer patients did not differ in parameters as compared to the control group supporting other reports of intact occipital function at this stage of disease. Simultaneous assessment of electrical as well as vascular integrity might help in differentiating the most frequent forms of dementia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 257, Issues 1–2, 15 June 2007, Pages 149–154
نویسندگان
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