کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1916576 | 1535213 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Flow cytometry evaluation of the T-cell receptor Vβ repertoire among human T-cell lymphotropic virus type-1 (HTLV-1) infected individuals: Effect of interferon alpha therapy in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Human T-cell lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic inflammatory disease of the spinal cord characterized by perivascular lymphocytic cuffing and parenchymal lymphocytic infiltration. In this study using flow cytometry, we have investigated the T-cell receptor (TCR) Vβ repertoire of peripheral blood T lymphocytes in 8 HAM/TSP patients, 10 HTLV-1 infected healthy carriers, and 11 uninfected healthy controls to determine if there is a biased usage of TCR Vβ. We found that TCR Vβ7.2 was under-utilized and Vβ12 was over-utilized in CD4+ T cells of HTLV-1 infected individuals compared with healthy uninfected controls, whereas there were no such differences in CD8+ T cells. Comparison of Vβ repertoire changes before and after interferon-alpha (IFN-α) treatment for HAM/TSP revealed that one out of five patients showed dramatic decrease of specific Vβ in CD8+ T cells. Our results suggest that dominant Vβ subpopulations in CD4+ T cells evolved associated with chronic HTLV-1 infection, and IFN-α treatment for HAM/TSP does not induce a specific pattern of TCR Vβ changes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 246, Issues 1â2, 15 July 2006, Pages 37-43
Journal: Journal of the Neurological Sciences - Volume 246, Issues 1â2, 15 July 2006, Pages 37-43
نویسندگان
Mineki Saito, Hirohisa Nose, Koichiro Usuku, Amir H. Sabouri, Toshio Matsuzaki, Shuji Izumo, Kimiyoshi Arimura, Mitsuhiro Osame,