کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1920564 1048719 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Experimental support that ocular tremor in Parkinson's disease does not originate from head movement
ترجمه فارسی عنوان
حمایت تجربی که لرزش چشم در بیماری پارکینسون از حرکت سر آغاز نمی کند
کلمات کلیدی
لرزش چشم، بیماری پارکینسون، صفحه نوشیدنی اسیلوسپس بیومارکر، حرکات چشم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی

IntroductionOur recent report of ocular tremor in Parkinson's disease (PD) has raised considerable controversy as to the origin of the tremor. Using an infrared based eye tracker and a magnetic head tracker, we reported that ocular tremor was recordable in PD subjects with no apparent head tremor. However, other investigators suggest that the ocular tremor may represent either transmitted appendicular tremor or subclinical head tremor inducing the vestibulo-ocular reflex (VOR). The present study aimed to further investigate the origin of ocular tremor in PD.MethodsEye movements were recorded in 8 PD subjects both head free, and with full head restraint by means of a head holding device and a dental impression bite plate. Head movements were recorded independently using both a high sensitivity tri-axial accelerometer and a magnetic tracking system, each synchronized to the eye tracker.ResultsOcular tremor was observed in all 8 PD subjects and was not influenced by head free and head fixed conditions. Both magnetic tracking and accelerometer recordings supported that the ocular tremor was fully independent of head position.ConclusionThe present study findings support our initial findings that ocular tremor is a fundamental feature of PD unrelated to head movements. Although the utility of ocular tremor for diagnostic purposes requires validation, current findings in large cohorts of PD subjects suggest its potential as a reliable clinical biomarker.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 20, Issue 7, July 2014, Pages 743–747
نویسندگان
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