کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1920566 1048719 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differentiation of early-stage parkinsonisms using neuromelanin-sensitive magnetic resonance imaging
ترجمه فارسی عنوان
تمایز پارکینسونیسم در مراحل اولیه با استفاده از تصویربرداری رزونانس مغناطیسی حساس به نوروملنین
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی

PurposeThe purpose of this study was to investigate whether the signal intensity of the substantia nigra pars compacta (SNc) and locus coeruleus (LC) on neuromelanin-sensitive magnetic resonance imaging (MRI) can discriminate early-stage parkinsonism disorders, for which differential diagnosis is generally difficult.MethodsNeuromelanin-sensitive MRI at 3 T was performed in 53 patients with early parkinsonism and 22 healthy controls. After an observation period of >1.5 year, the patients were clinically diagnosed with Parkinson's disease (PD; n = 30), multiple system atrophy with predominant parkinsonism (MSA-P; n = 10), or progressive supranuclear palsy syndrome (PSPS; n = 13). The signal intensity of the lateral, central, and medial parts of the SNc and the LC were measured and the contrast ratios (CR) against adjacent white-matter structures was calculated.ResultsThe CR of the lateral SNc was lower in the PD and MSA-P groups than in the PSPS and control groups (p = 0.0001–0.05). The CR of the LC was lower in the PD group than in the other groups (p = 0.0001–0.05). Sensitivity and specificity of the CRs for discriminating PD from MSA-P was 60% and 90%, respectively, those for PD/PSPS were 63–88% and 77–92%, respectively, and those for MSA-P/PSPS were 80% and 85%, respectively. These properties were comparable or better to MIBG scintigraphy.ConclusionsNeuromelanin-sensitive MRI can depict differences in signal intensity of the lateral SNc and the LC among the parkinsonism disorders at their early stages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 20, Issue 7, July 2014, Pages 755–760
نویسندگان
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