کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1921401 | 1048769 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The time course of the return of upper limb bradykinesia after cessation of subthalamic stimulation in Parkinson's disease
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
To investigate the time span within which bradykinesia re-occurs, we registered movement parameters immediately after the termination of deep brain stimulation of the subthalamic nucleus (STN) in nine Parkinson patients with chronically implanted bilateral STN electrodes. Two repetitive movements were investigated: finger-tapping and forearm pronation-supination. When stimulation was switched off, the amplitude and velocity of the investigated movements significantly declined, but the frequency did not. The time course of this decline was modeled by an exponential function that yielded time constants between 15 and 30Â s. The effect of stimulation had completely disappeared within 1Â min. These results suggest that it is necessary to wait at least for 1Â min after the end of stimulation before performing further assessments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 13, Issue 7, October 2007, Pages 438-442
Journal: Parkinsonism & Related Disorders - Volume 13, Issue 7, October 2007, Pages 438-442
نویسندگان
Zoltan Keresztenyi, Peter ValkoviÄ, Thomas Eggert, Ulrich Steude, Joachim Hermsdörfer, Jozsef Laczko, Kai Bötzel,