کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1921484 1048773 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dopamine β-hydroxylase −1021C>T association and Parkinson's disease
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Dopamine β-hydroxylase −1021C>T association and Parkinson's disease
چکیده انگلیسی
A single nucleotide polymorphism in the promoter region of the dopamine β-hydroxylase gene (DBH −1021C > T; rs1611115) is reported to regulate plasma enzyme activity levels. This variant has also been the focus of two large association studies in Parkinson's disease yielding conflicting results. We examined this association in four Caucasian patient-control series (n = 2696). A modest protective association was observed in the Norwegian series (OR = 0.81, p = 0.03; n = 1676), however, the effect was in the opposite direction in the Polish series (OR = 2.01, p = 0.01; n = 224). No association was observed for DBH −1021C > T with disease susceptibility in the US and Irish series, or combining all four series (OR = 0.91, p = 0.16, n = 2696). We observed a modest association between DBH −1021C > T and AAO in the combined series (p = 0.01). Taken together, these findings indicate that DBH −1021C > T does not play a major role in the pathogenesis of Parkinson's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 14, Issue 7, November 2008, Pages 544-547
نویسندگان
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