کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1921728 | 1048780 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alpha-synuclein and autophagy as common steps in neurodegeneration
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The major component of Lewy bodies in Parkinson's disease (PD) is α-synuclein, which is considered as a substrate of the ubiquitin–proteasome (UP) system, although autophagy seems to be equally involved. Here we discuss the co-existence of α-synuclein and proteins belonging to the UP system within autophagic granules, further developing as neuronal inclusions. We hypothesize that, following slight insults, both UP and autophagy are induced; if toxic stimuli are prolonged, these pathways are overwhelmed and cell death occurs. We then indicate a protective role of autophagy in PD and suggest it as a therapeutic target to slow down the progression of the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 14, Supplement 2, July 2008, Pages S180–S184
Journal: Parkinsonism & Related Disorders - Volume 14, Supplement 2, July 2008, Pages S180–S184
نویسندگان
Michela Ferrucci, Livia Pasquali, Stefano Ruggieri, Antonio Paparelli, Francesco Fornai,