کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1922548 | 1048813 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel pattern of levodopa-related motor fluctuations: 'Paradoxical' on
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel pattern of levodopa-related motor fluctuations: 'Paradoxical' on Novel pattern of levodopa-related motor fluctuations: 'Paradoxical' on](/preview/png/1922548.png)
چکیده انگلیسی
Generally, motor functions of Parkinson disease (PD) patients become worse as levodopa wears off. Recently, we encountered four PD patients who reported that their motor functions get better after levodopa wears off. These patients were admitted and the pattern of motor fluctuations was monitored. All showed a novel pattern where motor function spontaneously got better near to on level without medication after the effect of levodopa wore off. We call this 'paradoxical' on because motor functions get paradoxically better when levodopa is most likely washed out from the body. Pathomechanism of 'paradoxical' on is uncertain and needs further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parkinsonism & Related Disorders - Volume 14, Issue 4, May 2008, Pages 281-285
Journal: Parkinsonism & Related Disorders - Volume 14, Issue 4, May 2008, Pages 281-285
نویسندگان
Han-Joon Kim, Ji-Young Kim, Sun Ha Paek, Beom S. Jeon,