کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1923983 1048926 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of α-gustducin in the circumvallate papillae of taste buds of diabetic rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Expression of α-gustducin in the circumvallate papillae of taste buds of diabetic rats
چکیده انگلیسی
Taste impairment is a complication of Diabetes mellitus and some studies have shown this taste disorder in diabetes. Diabetes can decrease the ability of individuals to detect and recognize sweet, salty and bitter tastes. α-Gustducin is a transducin-like G-protein selectively expressed in 20 - 30% of taste receptor cells, which has been shown to be involved in bitter, sweet and umami taste responses. The present study was performed to explore the protein and mRNA expression of α-gustducin in the taste buds of diabetic and control rat circumvallate papillae. Our results showed that the positive expression of α-gustducin in diabetic rat taste bud cells is higher than that in normal controls as shown by both immunohistochemistry and RT-PCR. There may be some variant of bitter, sweet or umami taste transduction during diabetes and that taste transduction variant may be one cause of diabetic taste impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 111, Issue 2, March 2009, Pages 145-149
نویسندگان
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