کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1924158 | 1535862 | 2008 | 6 صفحه PDF | دانلود رایگان |

SummaryThe extensive actin cytoskeletal remodelling of the uterine stroma during early pregnancy involves changes in actin-binding proteins. This study provides the first detailed localisation of the actin-binding protein, moesin, in rat uterine endometrium during this period. Western blot analysis and immunofluorescence microscopy showed that the amount of moesin in the uterus peaked at the time of implantation, corresponding to the presence of intensely immunolabelling decidual cells. Furthermore, moesin increased in active membrane/cytoskeleton bound protein at the time of implantation, concomitantly decreasing in cytosolic protein. The increase of moesin at decidualisation corresponds with the appearance of alpha smooth muscle actin (αSMA) suggesting that decidual cells have contractile abilities that may aid in containing an invasive trophoblast. The results of this study suggest that moesin is important in developing a specialised cytoskeleton and increased adhesiveness of decidual cells, possibly functioning to bridge adhesion molecules to the underlying cytoskeleton.
Journal: Acta Histochemica - Volume 110, Issue 6, November 2008, Pages 491–496