کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1924228 | 1048947 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of high levels of progesterone on α1-integrin distribution in the endometrium of patients with unexplained infertility
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Irregular or low expression of integrins, which are cell adhesion molecules, may be associated with infertility. We conducted a prospective controlled study evaluating the effects of supraphysiological levels of estrogen and progesterone created by human menopausal gonadotropins (HMG) and progesterone support on α1-integrin immunolocalisation in the endometrium. Three groups were enrolled in the study. The first group of patients (group 1) had unexplained infertility and had been treated with HMG and progesterone (n=27). The second group of patients (group 2) was an untreated fertile group (n=24). The third group (group 3) consisted of patients who had unexplained infertility and had received no treatment (n=11). Endometrial biopsy specimens were taken from individuals from each group during the ovulation induction period. α1-integrin immunohistochemistry was performed. Serum estradiol and progesterone levels were also measured in parallel with histological dating of endometrial biopsies. Group 1 showed no statistical difference from group 2 in α1-integrin or histological dating. Group 3 showed less α1-integrin in the glandular epithelium in the secretory phase. We observed that α1-integrin was specific to the secretory phase. Its localization was denser in group 2 when compared with group 3, which supports the conclusion that α1-integrin may be a useful marker for luteal phase quality. Moreover, the supraphysiological estrogen and progesterone levels created by HMG and progesterone support may affect the α1-integrin in the endometrium in the secretory phase in the case of unexplained infertile patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 110, Issue 5, 8 September 2008, Pages 363-370
Journal: Acta Histochemica - Volume 110, Issue 5, 8 September 2008, Pages 363-370
نویسندگان
Sevtap Kilic, Tahir Hatipoglu, Deniz Erdogan, Cigdem Elmas, Beril Yuksel, Nicel Tasdemir, Nafiye Yilmaz, Sertac Batioglu,