کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1924315 1048953 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lectin binding and effects in culture on human cancer and non-cancer cell lines: Examination of issues of interest in drug design strategies
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Lectin binding and effects in culture on human cancer and non-cancer cell lines: Examination of issues of interest in drug design strategies
چکیده انگلیسی
Both cell lines bound to DBA-derivatized microbeads, and binding was inhibited by N-acetyl-d-galactosamine, but not by l-fucose. Neither cell line bound to PNA-derivatized microbeads. Despite the lack of lectin binding using the rapid microbead method, PNA was mitogenic in culture at some time points and its mitogenic effect displayed a reverse-dose response. This was also seen with effects of DBA on cells in culture. While this is a simple study, the results were statistically highly significant and suggest that: (1) agents may not need to bind strongly to cells to exert biological effects, (2) cell line pairs derived from diseased and non-diseased tissue can provide useful comparative data on potential drug effects and (3) very low concentrations of potential drugs might be initially tested experimentally because reverse-dose responses should be considered.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Histochemica - Volume 109, Issue 6, 10 November 2007, Pages 491-500
نویسندگان
, , ,