کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1972914 | 1060300 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stress activated protein kinases, JNKs and p38 MAPK, are differentially activated in ganglia and heart of land snail Helix lucorum (L.) during seasonal hibernation and arousal
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The present work aimed to investigate the phosphorylation and hence activation of stress activated protein kinases, p38 MAPK and JNKs in the tissues of the snail Helix lucorum during seasonal hibernation. Snails were put in large glass boxes, which were placed outdoors so that they were exposed to natural conditions of light and temperature. Phosphorylation and hence activation of JNKs and p38 MAPK was determined in both heart and ganglia. Deep hibernation caused significant increases in the levels of the phosphorylated form of JNK and p38-MAPK in both heart and ganglia. Phosphorylation of JNK remained elevated in the ganglia or increased after a transient drop in the heart, when the snails were prepared for arousal. In addition, phosphorylation of p38-MAPK was further increased in the heart during this period. These data support the conclusion that MAPK signalling cascade might contribute in the physiological and biochemical remodelling in the tissues of land snails during hibernation and upon preparation for arousal.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 153, Issue 2, June 2009, Pages 149-153
Journal: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology - Volume 153, Issue 2, June 2009, Pages 149-153
نویسندگان
Basile Michaelidis, Maria Hatzikamari, Vassiliki Antoniou, Andreas Anestis, Antigone Lazou,