Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats

• Urotensin II receptors has an important role in the physiopathogenesis of acute inflammatory response.
• UT-II receptor stimulation via agonist did not aggrevate carrageenan induced inflammation.
• Urotensin II receptor antagonist significantly prevented the decrease in antioxidant system and increase inflammatory responses.
• UT-II may responsible from development of inflammatory process but may has insignificant effect of the severity of inflammation.

This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation. Rats were divided into 5 groups as (1) Healthy control, (2) Carrageenan control, (3) Carrageenan +Indomethacin 20 mg/kg, orally, (4) Carrageenan +AC7954 (U-II receptor agonist, intraperitoneally) 30 mg/kg and (5) Carrageenan +SB657510 (UTR antagonist, intraperitoneally) 30 mg/kg. 1 h after drug administration, carrageenan was injected. At the 3rd hour after carrageenan injection, agonist produced no effect while antagonist 63% anti-inflammatory effect respectively. UTR and UT-II expression increased in carrageenan induced paw tissue. Antagonist administration prevented the decrease in an antioxidant system and also capable to decrease TNF-α and IL-6 mRNA expressions. This study showed the role of urotensin II receptors in the physiopathogenesis of acute inflammatory response that underlying many diseases accompanied by inflammation.

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