کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2006074 | 1541723 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
One dose of oral hexarelin protects chronic cardiac function after myocardial infarction
ترجمه فارسی عنوان
یک دوز هگزارلین خوراکی از فعالیت قلبی مزمن پس از انفارکتوس میوکارد محافظت می کند
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کلمات کلیدی
LV end-systolic diameterpercentage fractional shortening%FSTibial lengthNHFNLFLVDsLF/HFLV end-diastolic diameterLVDdSNAMyocardial infarction - آنفارکتوس میوکاردleft ventricle - بطن چپGrowth hormone secretagogues - ترشح هورمون رشدSympathetic nerve - عصب سمپاتیکCardiac function - عملکرد قلبیSympathetic nervous activity - فعالیت عصبی سمپاتیکHexarelin - هگزاللینbody weight - وزن بدنlung weight - وزن ریهHeart weight - وزن قلب
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Both hexarelin and its natural analog ghrelin exert comparable cardioprotective activities. A single dose of ghrelin administered at the very acute phase after experimental myocardial infarction positively affects cardiac function in chronic heart failure. Therefore, this study aimed to determine whether a single dose of oral hexarelin has the same effect in the chronic disease phase. Myocardial infarction or sham operation was generated by left coronary artery ligation in male C57BL/6J mice, which subsequently received one dose of hexarelin or vehicle treatment by oral gavage 30Â min after operation. Although the mortality within 14 days after myocardial infarction did not differ between the groups, hexarelin treatment protected cardiac function in the chronic phase as evidenced by higher ejection fraction and fractional shortening, as well as lower lung weight/body weight and lung weight/tibial length ratios, compared with vehicle treatment. Hexarelin treatment concurrently lowered plasma epinephrine and dopamine levels, and shifted the balance of autonomic nervous activity toward parasympathetic nervous activity as evidenced by a smaller low/high-frequency power ratio and larger normalized high-frequency power on heart rate variability analysis. The results first demonstrate that one dose of oral hexarelin treatment potentially protects chronic cardiac function after acute myocardial infarction, and implicate that activating growth hormone secretagogue receptor 1a might be beneficial for cardioprotection, although other mechanism may also be involved.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 56, June 2014, Pages 156-162
Journal: Peptides - Volume 56, June 2014, Pages 156-162
نویسندگان
Yuanjie Mao, Takeshi Tokudome, Ichiro Kishimoto, Kentaro Otani, Mikiya Miyazato, Kenji Kangawa,