کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2006122 1541725 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adrenomedullin alleviates pulmonary artery collagen accumulation in rats with pulmonary hypertension induced by high blood flow
ترجمه فارسی عنوان
آدنومدولین تجمع کلاژن شریان ریوی را در موشهای صحرایی با فشار خون ریوی ناشی از فشار خون بالا کاهش می دهد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• We explored the effects of ADM on pulmonary hypertension and pulmonary collagen remodeling induced by high blood flow.
• ADM plays a protective role in the development of pulmonary hypertension induced by high blood flow.
• ADM alleviates pulmonary artery collagen accumulation by inhibiting pulmonary procollagen synthesis.
• The effect of ADM on collagen metabolism might involve TGF-β1, a key extracellular matrix regulator.

Collagen accumulation is one of the important pathologic changes in the development of pulmonary hypertension. Previous research showed that adrenomedullin (ADM) mitigates the development of pulmonary hypertension. The present study explored the role of ADM in the development of pulmonary artery collagen accumulation induced by high pulmonary blood flow, by investigating the effect of ADM [1.5 μg/(kg h)] subcutaneously administered by mini-osmotic pump on pulmonary hemodynamics, pulmonary vascular structure and pulmonary artery collagen accumulation and synthesis in rats with high pulmonary blood flow induced by aortocaval shunting. The results showed that ADM significantly decreased mean pulmonary artery pressure (mPAP) and the ratio of right ventricular mass to left ventricular plus septal mass [RV/(LV + SP)], attenuated the muscularization of small pulmonary vessels and relative medial thickness (RMT) of pulmonary arteries in rats with high pulmonary blood flow. Meanwhile, ADM ameliorated pulmonary artery collagen deposition represented by a decrease in lung tissue hydroxyproline, collagens I and III content and pulmonary artery collagens I and III expression, reduced collagen synthesis represented by a decrease in lung tissue procollagens I and III mRNA expression. The results suggest that ADM plays a protective role in the development of pulmonary hypertension induced by high blood flow, by inhibiting pulmonary procollagen synthesis and alleviating pulmonary artery collagen accumulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 54, April 2014, Pages 101–107
نویسندگان
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