Esculentin-2CHa: A host-defense peptide with differential cytotoxicity against bacteria, erythrocytes and tumor cells

► Esculentin-2CHa potently inhibits growth of MRSA and multidrug-resistant Gram-negative bacteria. ► The full sequence of the peptide is required for high antimicrobial and cytotoxic activities. ► Esculentin-2CHa and its [D20K, D27K] analog show potential as anticancer agents.