Peripheral leptin and ghrelin receptors are regulated in a tissue-specific manner in activity-based anorexia

Under prolonged negative energy balance conditions: ▶ Visceral and gonadal fat participate more than subcutaneous fat in hypoleptinemia. ▶ Oxidative-soleus muscle appears to be more sensitive to ghrelin and leptin than glycolytic-gastrocnemius muscle. ▶ Only subcutaneous fat express the active LEPR form. ▶ Chronic hyperghrelinemia prevents lipid loss on visceral and subcutaneous fat by inducing GHS-R1a expression.