Kinin generation from exogenous kininogens at the surface of retinoic acid-differentiated human neuroblastoma IMR-32 cells after stimulation with interferon-γ

► Kininogens bind to retinoic acid-differentiated human neuroblastoma IMR-32 cells. ► These neuronal cells produce kinins and des-Arg-kinins from exogenous kininogens. ► The production of these peptides increases after cell stimulation with interferon-γ. ► Stimulated cells express tissue kallikrein, carboxypeptidase M and kinin receptors. ► Particularly, the des-Arg-kinin-specific B1-type receptors are highly induced.