کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2006486 1066342 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Orexins increase penicillin-induced epileptic activity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Orexins increase penicillin-induced epileptic activity
چکیده انگلیسی

Orexins have been implicated with physiological function including sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on excitability are controversial. We investigated the effects of intracortical injections of orexin A (100 pmol) and B (100 pmol) on the electrophysiological manifestation of epileptic seizures induced by cortical penicillin application in adult male rats. In comparison to saline, orexin A and B enhanced significantly the spike number, spike amplitude and spectral power values induced by cortical penicillin. Our findings indicates that orexins enhances the hyperexcitable and hypersyncronic cortical epileptic activity induced by focal application of penicillin-G.


► Orexins are excitatory neuropeptides.
► We investigate the effects of orexins on penicillin-induced epilepsy in rats.
► Orexins cause dramatically increase penicillin-induced epileptic activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 34, Issue 2, April 2012, Pages 419–422
نویسندگان
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