کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2006503 | 1066343 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the caudate nucleus to participate in pain modulation Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the caudate nucleus to participate in pain modulation](/preview/png/2006503.png)
Arginine vasopressin (AVP), which is synthesized and secreted in the hypothalamic paraventricular nucleus (PVN), is the most important bioactive substance in the pain modulation. Our pervious study had shown that AVP plays an important role in pain modulation in caudate nucleus (CdN). The experiment was designed to investigate the source of AVP in CdN by the nucleus push–pull perfusion and radioimmunoassay. The results showed that: (1) pain stimulation increased the AVP concentration in the CdN perfusion liquid, (2) PVN decreased the effect of pain stimulation which was stronger in both sides than in one side of PVN cauterization; and (3) L-glutamate sodium would excited the PVN neurons by the PVN microinjection that could increase the AVP concentration in the CdN perfusion liquid. The data suggested that AVP in the CdN might come from the PVN in the pain process, i.e., AVP in the PVN might be transferred to the CdN to participate in the pain modulation.
Research highlights▶ Pain stimulation increased AVP concentration in CdN perfusion liquid. ▶ PVN cauterization inhibited AVP increase in CdN perfusion liquid induced by pain stimulation. ▶ Role of AVP increase in CdN perfusion liquid was stronger in both sides of PVN cauterization than that in one sides of PVN cauterization during pain process. ▶ PVN neuron stimulation could increase AVP concentration in CdN perfusion liquid.
Journal: Peptides - Volume 32, Issue 1, January 2011, Pages 71–74