Effects of endomorphins on human umbilical vein endothelial cells under high glucose

▶ The high glucose induced increase in expression of NO, NOS and ET-1 were significantly attenuated by pretreatment with endomorphin1/endomorphin2. ▶ Naloxone, do not influence the mRNA eNOS expression when it is administrated alone; but it could significantly antagonize the effects induced by EM1/EM2. ▶ These findings have revealed the molecular mechanism of endomorphins on protecting HUVECs from harmful conditions induced by high glucose.