Urotensin II differentially regulates macrophage and hepatic cholesterol homeostasis

► Urotensin II gene deletion decreases LDL cholesterol profile and liver steatosis. ► Urotensin II gene deletion increases macrophage cholesterol synthesis. ► Urotensin II gene deletion decrease hepatocyte cholesterol synthesis. ► Urotensin II gene deletion decreases hepatocytes ApoB lipoproteins secretion.