کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2006556 1066345 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuromedin S regulates cardiovascular function through the sympathetic nervous system in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Neuromedin S regulates cardiovascular function through the sympathetic nervous system in mice
چکیده انگلیسی

Intracerebroventricular (icv) injection of neuromedin S (NMS) in mice increased the heart rate in a dose-dependent manner. On the other hand, genetically NMS deficient mice (NMS-KO mice) exhibited a decreased heart rate and significant extension of the QRS and PR interval in the electrocardiogram complex. Although treatment with a parasympathetic nerve blocker, methylscopolamine, and a sympathetic nerve blocker, timolol, respectively increased and decreased the heart rate in both NMS-KO and wild-type mice, the extent of the decrease induced by timolol was smaller in NMS-KO than in wild-type mice. In addition, pretreatment with timolol completely inhibited the NMS-induced heart rate increase in wild-type mice. No expression of mRNA for NMS or the NMS receptor was evident in the heart by RT-PCR analysis. These results suggest that endogenous NMS may regulate cardiovascular function by activating the sympathetic nervous system.


► Administration of neuromedin S increases heart rate in mouse.
► Neuromedin S-KO mouse exhibits a decreased heart rate.
► Sympathetic nerve blocker inhibits the neuromedin S-induced increase of heart rate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 32, Issue 5, May 2011, Pages 1020–1026
نویسندگان
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