Post-natal stress-induced endocrine and metabolic alterations in mice at adulthood involve different pro-opiomelanocortin-derived peptides

▶ Post-natal complex stress induce type-2 diabetes signs in adult male mice. ▶ Some signs depend on the endogenous opioid system upset and are prevented by naloxone. ▶ Other diabetes signs depend on HPA hormones upset. ▶ All diabetes signs are prevented by antisense oligonucleotide versus pro-opiomelanocortin. ▶ Different diabetes signs in our model are modulated through different pathogenetic mechanisms.