Angiotensin-(1-7) attenuates hyposmolarity-induced ANP secretion via the Na+-K+ pump

▶ Perfusion of hyposmolar solution into the atria increased the ANP secretion. ▶ Ang-(1-7) decreased the hyposmolarity-induced ANP secretion via Na+-K+ pump. ▶ In DM atria, the response of ANP secretion to hyposmolar solution was robustly accentuated. ▶ Ang-(1-7) had no effect on hyposmolarity-induced ANP secretion in DM atria partly because of potent inhibition of Na+-K+ pump.