کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2007021 1066361 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role and action in the pituitary corticotroph of corticotropin-releasing factor (CRF) in the hypothalamus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Role and action in the pituitary corticotroph of corticotropin-releasing factor (CRF) in the hypothalamus
چکیده انگلیسی

Corticotropin-releasing factor (CRF), produced in the hypothalamic paraventricular nucleus (PVN) in response to stress, stimulates the synthesis and secretion of adrenocorticotropin (ACTH) via CRF receptor type 1 (CRF1 receptor) in the anterior pituitary (AP) of mammals. CRF is critical for the circadian rhythmicity of the hypothalamic–pituitary–adrenal axis and the augmented release of ACTH from the pituitary in response to the stress. A higher molecular weight form of immunoreactive β-endorphin, putative proopiomelanocortin (POMC), is increased in CRF-knockout mice (CRF KO), suggesting the important role of CRF in the processing of POMC. In fact, CRF is able to modulate the processing of POMC through changes in prohormone convertase (PC)-1 expression levels. Multiple forms of ACTH-related peptides containing unprocessed ones are present in some cases of ACTH-producing tumors, presumably without action of PC-1 under the control of CRF. Following CRF-activated stimulation of the receptor signaling, CRF1 receptor is down-regulated and desensitized. In fact, CRF facilitates the degradation of CRF1 receptor mRNA via the protein kinase A pathway. Prolonged agonist activation of CRF1 receptor leads to a loss of responsiveness, or desensitization of the receptor. G protein-coupled receptor kinase 2 is involved in desensitization of CRF1 receptor by CRF in the corticotroph.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 30, Issue 4, April 2009, Pages 810–816
نویسندگان
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