کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2007110 1066364 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel conopeptides in a form of disulfide-crosslinked dimer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Novel conopeptides in a form of disulfide-crosslinked dimer
چکیده انگلیسی
In our present work, seven conotoxins and conopeptides were cloned from four cone snail species based on the M-superfamily signal peptides. Among them, two conopeptides, Vt3.1 and Vt3.2, showed unusual sequence characteristics. Both of them contained two cysteines that are separated by just one non-cysteine residue. In vitro, the chemically synthesized Vt3.1 formed dimers with different intermolecular disulfide linkages. Only the dimer with crossed disulfides showed bioactivity when injected into the intraventricular region of mice brains. Therefore, Vt3.1 and Vt3.2 represent a new group of conopeptides that form disulfide-crosslinked dimers in vitro and probably in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 31, Issue 6, June 2010, Pages 1001-1006
نویسندگان
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