کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2007150 1066365 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biological properties and functional determinants of the urotensin II receptor
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Biological properties and functional determinants of the urotensin II receptor
چکیده انگلیسی

The urotensin II receptor (UT) is a member of the G protein-coupled receptor (GPCR) family and binds the cyclic undecapeptide urotensin II (U-II) as well as the octapeptide urotensin II-related peptide (URP). The active UT mediates pleiotropic effects through various signal transduction pathways, including coupling to G proteins and activating the mitogen-activated protein kinase pathway. Several highly conserved residues and motifs of class A GPCRs that are important for activity are found in UT. This review highlights some of the putative roles of these motifs in the binding, activation and desensitization of UT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 29, Issue 5, May 2008, Pages 691–699
نویسندگان
, , , , , ,