کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2007200 1066366 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Pacifastin-related peptides: Structural and functional characteristics of a family of serine peptidase inhibitors
چکیده انگلیسی

Members of the pacifastin family are serine peptidase inhibitors, found in arthropods and have many members within different insect orders. Based on their structural characteristics, inhibitors of this peptide family are divided into two groups (I and II). Members of both groups exhibit specificity towards different types of serine peptidases. In addition, group I inhibitors display species selectivity. The specificity and selectivity of these inhibitors depends on the nature of their P1 residue and on additional interaction sites at the inhibitor's surface. Functional analysis studies have shown that crustacean pacifastin plays a key role in the immune response, whereas insect pacifastin-like peptides have multiple regulatory functions in processes involved in immunity, reproduction, phase transition, etc.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 30, Issue 3, March 2009, Pages 622–632
نویسندگان
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