کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2007231 | 1066367 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of novel synthetic peptide showing angiogenic activity in human endothelial cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of novel synthetic peptide showing angiogenic activity in human endothelial cells Identification of novel synthetic peptide showing angiogenic activity in human endothelial cells](/preview/png/2007231.png)
چکیده انگلیسی
A novel synthetic hexapeptide (SFKLRY-NH2) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). The peptide induced proliferation, migration, and capillary-like tube formation in primary cultured HUVECs, and augmented vessel sprouting ex vivo while attenuated by the treatment with pertussis toxin (PTX) or U73122 (PLC-inhibitor) suggesting the influence of PTX-sensitive G-proteins and PLC. In addition, SFKLRY-NH2 up-regulated the expression of VEGF-A in HUVECs and the neutralizing antibody against VEGF suppressed SFKLRY-NH2-induced tube formation activity. Taken together, these results suggest that SFKLRY-NH2 may induce blood vessel formation by PTX-sensitive G protein-coupled receptor-PLC-Ca2+ signaling cascade leading into VEGF-A expression in HUVECs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 30, Issue 2, February 2009, Pages 409-418
Journal: Peptides - Volume 30, Issue 2, February 2009, Pages 409-418
نویسندگان
Chang Hee Lee, Mi-sook Lee, Sun-jin Kim, Young-tae Je, Sung Ho Ryu, Taehoon Lee,