کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2007554 1066379 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Copper (II) modulates in vitro aggregation of a tau peptide
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Copper (II) modulates in vitro aggregation of a tau peptide
چکیده انگلیسی

Copper (II) has been implicated in the pathology of Alzheimer's disease (AD) for the impaired homeostatic mechanism found in the brains of AD patients. Here we studied the binding properties of Cu(II) with the first microtubule-binding repeat, encompassing residues 256–273 of the human tau441 sequence. Additionally, the effect of Cu(II) on the assembly of this repeat was also investigated. Our results indicate that Cu(II) can bind to this repeat with His268 involved and has an inhibiting effect on the in vitro aggregation of this repeat. This work provides new insight into the role of Cu(II) in Alzheimer's disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 28, Issue 11, November 2007, Pages 2229–2234
نویسندگان
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